Are there nonstop flights from Milwaukee (MKE) to Charleston (CHS)?

No. The fastest connection is via Charlotte, about 2h 33m of total flying time.

What is the fastest connection from Milwaukee (MKE) to Charleston (CHS)?

via Charlotte ≈ 2h 33m, via Chicago ≈ 2h 34m, via Chicago ≈ 2h 34m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

General Mitchell International Airport (MKE) to Charleston International Airport (CHS)・1,312 km

No nonstop flights. The fastest connection is via Charlotte (CLT), about 2h 33m of flying time (layover not included).

With milesJAL 12,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

24 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.