Are there nonstop flights from Miami (MIA) to Santa Cruz (VVI)?

Yes. Boliviana de Aviación fly this route. Flight time is about 6h 35m.

What is the fastest connection from Miami (MIA) to Santa Cruz (VVI)?

via Bogota ≈ 7h 7m, via Panama City ≈ 7h 16m, via Lima ≈ 7h 53m (estimated flying time, excluding layovers).

from 30,000 ANA miles (economy, one way, based on the published award charts).

Miami International Airport (MIA) to Viru Viru International Airport (VVI)・5,174 km

Nonstop flights available (1 airline). Flight time about 6h 35m. Nonstop return flights also operate.

With milesANA 30,000 miles+ (via BOG)Economy, one way, estimate. Tap a connection for miles by cabin.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.