Are there nonstop flights from Manta (MEC) to Quito (UIO)?

Yes. Avianca Ecuador, LATAM Airlines Ecuador, Aeroregional fly this route. Flight time is about 49m.

Manta → Quito

Eloy Alfaro International Airport (MEC) to Mariscal Sucre International Airport (UIO)・274 km

Nonstop flights available (3 airlines). Flight time about 49m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.