Are there nonstop flights from Chicago (MDW) to Palermo (PMO)?

No. The fastest connection is via Newark, about 10h 47m of total flying time.

What is the fastest connection from Chicago (MDW) to Palermo (PMO)?

via Newark ≈ 10h 47m (estimated flying time, excluding layovers).

Chicago Midway International Airport (MDW) to Falcone–Borsellino Airport (PMO)・8,056 km

No nonstop flights. The fastest connection is via Newark (EWR), about 10h 47m of flying time (layover not included).

None.

1 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.