Are there nonstop flights from Chicago (MDW) to Istanbul (IST)?

No. The fastest connection is via Detroit, about 11h 26m of total flying time.

What is the fastest connection from Chicago (MDW) to Istanbul (IST)?

via Detroit ≈ 11h 26m, via Boston ≈ 11h 42m, via Newark ≈ 11h 49m (estimated flying time, excluding layovers).

Chicago Midway International Airport (MDW) to İstanbul Airport (IST)・8,792 km

No nonstop flights. The fastest connection is via Detroit (DTW), about 11h 26m of flying time (layover not included).

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.