Are there nonstop flights from Chicago (MDW) to Houston (HOU)?

Yes. Southwest Airlines fly this route. Flight time is about 2h 17m.

What is the fastest connection from Chicago (MDW) to Houston (HOU)?

via St Louis ≈ 2h 47m, via Memphis ≈ 2h 50m, via Indianapolis ≈ 2h 56m (estimated flying time, excluding layovers).

Chicago Midway International Airport (MDW) to William P. Hobby Airport (HOU)・1,510 km

Nonstop flights available (1 airline). Flight time about 2h 17m. Nonstop return flights also operate.

44 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.