Are there nonstop flights from Chicago (MDW) to Rome (FCO)?

No. The fastest connection is via Detroit, about 10h 10m of total flying time.

What is the fastest connection from Chicago (MDW) to Rome (FCO)?

via Detroit ≈ 10h 10m, via Boston ≈ 10h 21m, via Newark ≈ 10h 27m (estimated flying time, excluding layovers).

Chicago Midway International Airport (MDW) to Rome–Fiumicino Leonardo da Vinci International Airport (FCO)・7,746 km

No nonstop flights. The fastest connection is via Detroit (DTW), about 10h 10m of flying time (layover not included).

None.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.