Are there nonstop flights from Harrisburg (MDT) to Louisville (SDF)?

No. The fastest connection is via Washington, about 2h 2m of total flying time.

What is the fastest connection from Harrisburg (MDT) to Louisville (SDF)?

via Washington ≈ 2h 2m, via Philadelphia ≈ 2h 14m, via Detroit ≈ 2h 17m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

Harrisburg International Airport (MDT) to Louisville Muhammad Ali International Airport (SDF)・805 km

No nonstop flights. The fastest connection is via Washington (IAD), about 2h 2m of flying time (layover not included).

With milesJAL 12,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.