Are there nonstop flights from Harrisburg (MDT) to London (LHR)?

No. The fastest connection is via Boston, about 7h 48m of total flying time.

What is the fastest connection from Harrisburg (MDT) to London (LHR)?

via Boston ≈ 7h 48m, via Philadelphia ≈ 7h 51m, via Washington ≈ 8h 8m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Harrisburg International Airport (MDT) to London Heathrow Airport (LHR)・5,767 km

No nonstop flights. The fastest connection is via Boston (BOS), about 7h 48m of flying time (layover not included).

With milesANA 27,500 miles+ (via ORD)JAL 37,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.