Are there nonstop flights from Harrisburg (MDT) to São Paulo (GRU)?

No. The fastest connection is via Washington, about 10h 11m of total flying time.

What is the fastest connection from Harrisburg (MDT) to São Paulo (GRU)?

via Washington ≈ 10h 11m, via Miami ≈ 10h 39m, via Boston ≈ 10h 44m (estimated flying time, excluding layovers).

from 30,000 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Harrisburg International Airport (MDT) to São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU)・7,739 km

No nonstop flights. The fastest connection is via Washington (IAD), about 10h 11m of flying time (layover not included).

With milesANA 30,000 miles+ (via ORD)JAL 45,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.