Are there nonstop flights from Medellín (MDE) to Quito (UIO)?

Yes. Avianca Ecuador fly this route. Flight time is about 1h 24m.

What is the fastest connection from Medellín (MDE) to Quito (UIO)?

via Bogota ≈ 2h 5m, via Guayaquil ≈ 2h 34m, via Panamá City ≈ 2h 51m (estimated flying time, excluding layovers).

from 17,500 ANA miles (economy, one way, based on the published award charts).

Jose Maria Córdova International Airport (MDE) to Mariscal Sucre International Airport (UIO)・771 km

Nonstop flights available (1 airline). Flight time about 1h 24m. Nonstop return flights also operate.

With milesANA 17,500 miles+ (via BOG)Economy, one way, estimate. Tap a connection for miles by cabin.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.