Are there nonstop flights from Medellín (MDE) to San Salvador (SAL)?

Yes. Avianca El Salvador fly this route. Flight time is about 2h 30m.

What is the fastest connection from Medellín (MDE) to San Salvador (SAL)?

via Panama City ≈ 3h, via San José ≈ 3h 1m, via Guatemala City ≈ 3h 28m (estimated flying time, excluding layovers).

from 17,500 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Jose Maria Córdova International Airport (MDE) to El Salvador International Airport Saint Óscar Arnulfo Romero y Galdámez (SAL)・1,698 km

Nonstop flights available (1 airline). Flight time about 2h 30m. Nonstop return flights also operate.

With milesANA 17,500 miles+ (via PTY)JAL 23,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.