Are there nonstop flights from Medellín (MDE) to Rome (FCO)?

No. The fastest connection is via Madrid, about 12h 1m of total flying time.

What is the fastest connection from Medellín (MDE) to Rome (FCO)?

via Madrid ≈ 12h 1m, via Miami ≈ 13h 26m, via New York ≈ 13h 36m (estimated flying time, excluding layovers).

from 45,000 JAL miles (economy, one way, based on the published award charts).

Jose Maria Córdova International Airport (MDE) to Rome–Fiumicino Leonardo da Vinci International Airport (FCO)・9,359 km

No nonstop flights. The fastest connection is via Madrid (MAD), about 12h 1m of flying time (layover not included).

With milesJAL 45,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.