Are there nonstop flights from Madrid (MAD) to Santiago (STI)?

Yes. Air Europa fly this route. Flight time is about 8h 23m.

What is the fastest connection from Madrid (MAD) to Santiago (STI)?

via San Juan ≈ 9h 5m, via Boston ≈ 10h 26m, via New York ≈ 10h 35m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Adolfo Suárez Madrid–Barajas Airport (MAD) to Cibao International Airport (STI)・6,704 km

Nonstop flights available (1 airline). Flight time about 8h 23m. Nonstop return flights also operate.

With milesANA 35,000 miles+ (via EWR)JAL 37,000 miles+ (via PHL)Economy, one way, estimate. Tap a connection for miles by cabin.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.