Are there nonstop flights from New York (LGA) to San Diego (SAN)?

No. The fastest connection is via Kansas City, about 5h 37m of total flying time.

What is the fastest connection from New York (LGA) to San Diego (SAN)?

via Kansas City ≈ 5h 37m, via Pittsburgh ≈ 5h 37m, via Columbus ≈ 5h 37m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

LaGuardia Airport (LGA) to San Diego International Airport (SAN)・3,920 km

No nonstop flights. The fastest connection is via Kansas City (MCI), about 5h 37m of flying time (layover not included).

With milesANA 15,000 miles+ (via ORD)JAL 23,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

38 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.