Are there nonstop flights from New York (LGA) to Indianapolis (IND)?

Yes. American Eagle (airline brand), Delta Connection fly this route. Flight time is about 1h 45m.

What is the fastest connection from New York (LGA) to Indianapolis (IND)?

via Washington ≈ 2h 20m, via Washington ≈ 2h 21m, via Detroit ≈ 2h 23m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

LaGuardia Airport (LGA) to Indianapolis International Airport (IND)・1,060 km

Nonstop flights available (2 airlines). Flight time about 1h 45m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via DCA)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.