Are there nonstop flights from New York (LGA) to Destin (DSI)?

Yes. Delta Connection fly this route. Flight time is about 2h 24m.

What is the fastest connection from New York (LGA) to Destin (DSI)?

via Washington ≈ 2h 54m, via Charlotte ≈ 2h 55m, via Washington ≈ 2h 55m (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

LaGuardia Airport (LGA) to Destin Executive Airport (DSI)・1,618 km

Nonstop flights available (1 airline). Flight time about 2h 24m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

28 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.