Are there nonstop flights from Guiyang (KWE) to Seoul (ICN)?

Yes. 9 Air, Colorful Guizhou Airlines fly this route. Flight time is about 3h 6m.

What is the fastest connection from Guiyang (KWE) to Seoul (ICN)?

via Zhangjiajie ≈ 3h 36m, via Wuhan ≈ 3h 36m, via Yichang ≈ 3h 36m (estimated flying time, excluding layovers).

from 11,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Guiyang Longdongbao International Airport (KWE) to Incheon International Airport (ICN)・2,208 km

Nonstop flights available (2 airlines). Flight time about 3h 6m. Nonstop return flights also operate.

With milesANA 11,000 miles+ (via NKG)JAL 15,000 miles+ (via NKG)Economy, one way, estimate. Tap a connection for miles by cabin.

37 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.