Are there nonstop flights from Karachi (KHI) to Moscow (DME)?

No. The fastest connection is via Baku, about 5h 59m of total flying time.

What is the fastest connection from Karachi (KHI) to Moscow (DME)?

via Baku ≈ 5h 59m, via Tashkent ≈ 6h 24m, via Sharjah ≈ 6h 40m (estimated flying time, excluding layovers).

from 23,000 JAL miles, from 29,500 ANA miles (economy, one way, based on the published award charts).

Jinnah International Airport (KHI) to Domodedovo International Airport (DME)・4,143 km

No nonstop flights. The fastest connection is via Baku (GYD), about 5h 59m of flying time (layover not included).

With milesJAL 23,000 miles+ (via DXB)ANA 29,500 miles+ (via ADD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.