Are there nonstop flights from Reykjavík (KEF) to Chicago (MDW)?

No. The fastest connection is via Detroit, about 6h 42m of total flying time.

What is the fastest connection from Reykjavík (KEF) to Chicago (MDW)?

via Detroit ≈ 6h 42m, via Pittsburgh ≈ 7h 3m, via Boston ≈ 7h 11m (estimated flying time, excluding layovers).

Keflavik International Airport (KEF) to Chicago Midway International Airport (MDW)・4,735 km

No nonstop flights. The fastest connection is via Detroit (DTW), about 6h 42m of flying time (layover not included).

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.