Are there nonstop flights from Reykjavík (KEF) to Charleston (CHS)?

No. The fastest connection is via Newark, about 7h 6m of total flying time.

What is the fastest connection from Reykjavík (KEF) to Charleston (CHS)?

via Newark ≈ 7h 6m, via New York ≈ 7h 6m, via Boston ≈ 7h 7m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Keflavik International Airport (KEF) to Charleston International Airport (CHS)・5,188 km

No nonstop flights. The fastest connection is via Newark (EWR), about 7h 6m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)JAL 45,000 miles+ (via SEA)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

14 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.