Are there nonstop flights from Skiathos (JSI) to Madrid (MAD)?

No. The fastest connection is via Naples, about 3h 43m of total flying time.

What is the fastest connection from Skiathos (JSI) to Madrid (MAD)?

via Naples ≈ 3h 43m, via Bari ≈ 3h 44m, via Rome ≈ 3h 44m (estimated flying time, excluding layovers).

from 23,000 JAL miles (economy, one way, based on the published award charts).

Skiathos Island National Airport (JSI) to Adolfo Suárez Madrid–Barajas Airport (MAD)・2,307 km

No nonstop flights. The fastest connection is via Naples (NAP), about 3h 43m of flying time (layover not included).

With milesJAL 23,000 miles+ (via LCY)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

27 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.