Are there nonstop flights from Johannesburg (JNB) to Madrid (MAD)?

Yes. Air Europa fly this route. Flight time is about 10h 2m.

What is the fastest connection from Johannesburg (JNB) to Madrid (MAD)?

via Algiers ≈ 10h 38m, via Zanzibar ≈ 11h 56m, via Addis Ababa ≈ 12h 11m (estimated flying time, excluding layovers).

from 30,000 ANA miles, from 40,000 JAL miles (economy, one way, based on the published award charts).

O.R. Tambo International Airport (JNB) to Adolfo Suárez Madrid–Barajas Airport (MAD)・8,106 km

Nonstop flights available (1 airline). Flight time about 10h 2m. Nonstop return flights also operate.

With milesANA 30,000 miles+ (via ADD)JAL 40,000 miles+ (via LHR)Economy, one way, estimate. Tap a connection for miles by cabin.

16 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.