Are there nonstop flights from Islamabad (ISB) to Milan (MXP)?

No. The fastest connection is via Baku, about 7h 30m of total flying time.

What is the fastest connection from Islamabad (ISB) to Milan (MXP)?

via Baku ≈ 7h 30m, via Istanbul ≈ 7h 37m, via Tashkent ≈ 7h 43m (estimated flying time, excluding layovers).

from 29,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Islamabad International Airport (ISB) to Milan Malpensa International Airport (MXP)・5,502 km

No nonstop flights. The fastest connection is via Baku (GYD), about 7h 30m of flying time (layover not included).

With milesANA 29,500 miles+ (via IST)JAL 37,000 miles+ (via DXB)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.