Are there nonstop flights from Niš (INI) to Istanbul (IST)?

Yes. Air Serbia fly this route. Flight time is about 1h 13m.

What is the fastest connection from Niš (INI) to Istanbul (IST)?

via Belgrade ≈ 2h 11m, via Tivat ≈ 2h 18m, via Athens ≈ 2h 23m (estimated flying time, excluding layovers).

Niš Constantine the Great Airport (INI) to İstanbul Airport (IST)・610 km

Nonstop flights available (1 airline). Flight time about 1h 13m. Nonstop return flights also operate.

3 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.