Are there nonstop flights from Indianapolis (IND) to Madrid (MAD)?

No. The fastest connection is via Toronto, about 8h 58m of total flying time.

What is the fastest connection from Indianapolis (IND) to Madrid (MAD)?

via Toronto ≈ 8h 58m, via Boston ≈ 8h 59m, via Newark ≈ 9h 2m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Indianapolis International Airport (IND) to Adolfo Suárez Madrid–Barajas Airport (MAD)・6,752 km

No nonstop flights. The fastest connection is via Toronto (YYZ), about 8h 58m of flying time (layover not included).

With milesANA 27,500 miles+ (via IAD)JAL 37,000 miles+ (via PHL)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

18 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.