Are there nonstop flights from Indianapolis (IND) to Istanbul (IST)?

No. The fastest connection is via Detroit, about 11h 26m of total flying time.

What is the fastest connection from Indianapolis (IND) to Istanbul (IST)?

via Detroit ≈ 11h 26m, via Toronto ≈ 11h 27m, via Dublin ≈ 11h 27m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Indianapolis International Airport (IND) to İstanbul Airport (IST)・8,874 km

No nonstop flights. The fastest connection is via Detroit (DTW), about 11h 26m of flying time (layover not included).

With milesANA 27,500 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.