Are there nonstop flights from Houston (IAH) to Destin (DSI)?

No. The fastest connection is via Shreveport, about 2h 14m of total flying time.

What is the fastest connection from Houston (IAH) to Destin (DSI)?

via Shreveport ≈ 2h 14m, via Little Rock ≈ 2h 34m, via Dallas-Fort Worth ≈ 2h 39m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

George Bush Intercontinental Airport (IAH) to Destin Executive Airport (DSI)・854 km

No nonstop flights. The fastest connection is via Shreveport (SHV), about 2h 14m of flying time (layover not included).

With milesJAL 12,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.