Are there nonstop flights from Washington (IAD) to Karachi (KHI)?

No. The fastest connection is via Toronto, about 15h 23m of total flying time.

What is the fastest connection from Washington (IAD) to Karachi (KHI)?

via Toronto ≈ 15h 23m, via Istanbul ≈ 15h 32m, via Dubai ≈ 15h 46m (estimated flying time, excluding layovers).

from 40,000 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Washington Dulles International Airport (IAD) to Jinnah International Airport (KHI)・12,018 km

No nonstop flights. The fastest connection is via Toronto (YYZ), about 15h 23m of flying time (layover not included).

With milesANA 40,000 miles+ (via IST)JAL 45,000 miles+ (via DXB)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.