Are there nonstop flights from Hotan (HTN) to Guangzhou (CAN)?

Yes. Hainan Airlines fly this route. Flight time is about 4h 39m.

What is the fastest connection from Hotan (HTN) to Guangzhou (CAN)?

via Chengdu ≈ 5h 10m, via Chongqing ≈ 5h 12m, via Changsha ≈ 5h 28m (estimated flying time, excluding layovers).

from 10,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Hotan Airport (HTN) to Guangzhou Baiyun International Airport (CAN)・3,528 km

Nonstop flights available (1 airline). Flight time about 4h 39m. Nonstop return flights also operate.

With milesANA 10,000 miles+ (via TFU)JAL 23,000 miles+ (via XIY)Economy, one way, estimate. Tap a connection for miles by cabin.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.