Are there nonstop flights from Houston (HOU) to Knoxville/Maryville (TYS)?

Yes. Allegiant Air fly this route. Flight time is about 1h 59m.

What is the fastest connection from Houston (HOU) to Knoxville/Maryville (TYS)?

via Nashville ≈ 2h 33m, via Memphis ≈ 2h 34m, via Atlanta ≈ 2h 36m (estimated flying time, excluding layovers).

William P. Hobby Airport (HOU) to McGhee Tyson Airport (TYS)・1,257 km

Nonstop flights available (1 airline). Flight time about 1h 59m. Nonstop return flights also operate.

19 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.