Are there nonstop flights from Greenville/Greer/Spartanburg (GSP) to Istanbul (IST)?

No. The fastest connection is via Newark, about 11h 35m of total flying time.

What is the fastest connection from Greenville/Greer/Spartanburg (GSP) to Istanbul (IST)?

via Newark ≈ 11h 35m, via Washington ≈ 11h 36m, via Detroit ≈ 11h 58m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Greenville-Spartanburg International Airport (GSP) to İstanbul Airport (IST)・9,003 km

No nonstop flights. The fastest connection is via Newark (EWR), about 11h 35m of flying time (layover not included).

With milesANA 27,500 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.