Are there nonstop flights from Greenville/Greer/Spartanburg (GSP) to Cancún (CUN)?

No. The fastest connection is via Tampa, about 2h 57m of total flying time.

What is the fastest connection from Greenville/Greer/Spartanburg (GSP) to Cancún (CUN)?

via Tampa ≈ 2h 57m, via Atlanta ≈ 2h 57m, via Orlando ≈ 3h 1m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Greenville-Spartanburg International Airport (GSP) to Cancún International Airport (CUN)・1,606 km

No nonstop flights. The fastest connection is via Tampa (TPA), about 2h 57m of flying time (layover not included).

With milesJAL 15,000 miles+ (via CLT)ANA 15,000 miles+ (via IAH)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

18 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.