Are there nonstop flights from São Paulo (GRU) to Brussels (BRU)?

Yes. LATAM Brasil fly this route. Flight time is about 11h 51m.

What is the fastest connection from São Paulo (GRU) to Brussels (BRU)?

via Lisbon ≈ 12h 21m, via Porto ≈ 12h 21m, via Paris ≈ 12h 22m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU) to Brussels Airport (BRU)・9,651 km

Nonstop flights available (1 airline). Flight time about 11h 51m. Nonstop return flights also operate.

With milesANA 35,000 miles+ (via LIS)JAL 45,000 miles+ (via MAD)Economy, one way, estimate. Tap a connection for miles by cabin.

24 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.