Are there nonstop flights from Rome (FCO) to Karachi (KHI)?

No. The fastest connection is via Istanbul, about 7h 17m of total flying time.

What is the fastest connection from Rome (FCO) to Karachi (KHI)?

via Istanbul ≈ 7h 17m, via Istanbul ≈ 7h 17m, via Kuwait City ≈ 7h 24m (estimated flying time, excluding layovers).

from 23,000 JAL miles, from 29,500 ANA miles (economy, one way, based on the published award charts).

Rome–Fiumicino Leonardo da Vinci International Airport (FCO) to Jinnah International Airport (KHI)・5,335 km

No nonstop flights. The fastest connection is via Istanbul (SAW), about 7h 17m of flying time (layover not included).

With milesJAL 23,000 miles+ (via DXB)ANA 29,500 miles+ (via IST)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.