Are there nonstop flights from Rome (FCO) to Guayaquil (GYE)?

No. The fastest connection is via Madrid, about 13h 10m of total flying time.

What is the fastest connection from Rome (FCO) to Guayaquil (GYE)?

via Madrid ≈ 13h 10m, via Amsterdam ≈ 14h 6m, via Miami ≈ 14h 27m (estimated flying time, excluding layovers).

from 45,000 JAL miles (economy, one way, based on the published award charts).

Rome–Fiumicino Leonardo da Vinci International Airport (FCO) to José Joaquín de Olmedo International Airport (GYE)・10,344 km

No nonstop flights. The fastest connection is via Madrid (MAD), about 13h 10m of flying time (layover not included).

With milesJAL 45,000 miles+ (via MAD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

5 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.