Are there nonstop flights from Rome (FCO) to Key West (EYW)?

No. The fastest connection is via Miami, about 11h 2m of total flying time.

What is the fastest connection from Rome (FCO) to Key West (EYW)?

via Miami ≈ 11h 2m, via Boston ≈ 11h 20m, via Newark ≈ 11h 22m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Rome–Fiumicino Leonardo da Vinci International Airport (FCO) to Key West International Airport (EYW)・8,532 km

No nonstop flights. The fastest connection is via Miami (MIA), about 11h 2m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)JAL 37,000 miles+ (via PHL)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.