Are there nonstop flights from Rome (FCO) to Bilbao (BIO)?

Yes. Wizz Air, Volotea, Vueling fly this route. Flight time is about 1h 58m.

What is the fastest connection from Rome (FCO) to Bilbao (BIO)?

via Olbia ≈ 2h 33m, via Barcelona ≈ 2h 33m, via Firenze ≈ 2h 37m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Rome–Fiumicino Leonardo da Vinci International Airport (FCO) to Bilbao Airport (BIO)・1,251 km

Nonstop flights available (3 airlines). Flight time about 1h 58m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via MAD)ANA 15,000 miles+ (via MUC)Economy, one way, estimate. Tap a connection for miles by cabin.

47 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.