Are there nonstop flights from Key West (EYW) to Milan (MXP)?

No. The fastest connection is via Miami, about 10h 33m of total flying time.

What is the fastest connection from Key West (EYW) to Milan (MXP)?

via Miami ≈ 10h 33m, via Boston ≈ 10h 48m, via Newark ≈ 10h 50m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Key West International Airport (EYW) to Milan Malpensa International Airport (MXP)・8,122 km

No nonstop flights. The fastest connection is via Miami (MIA), about 10h 33m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)JAL 37,000 miles+ (via PHL)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.