Are there nonstop flights from Dushanbe (DYU) to Karachi (KHI)?

No. The fastest connection is via Islamabad, about 3h 5m of total flying time.

What is the fastest connection from Dushanbe (DYU) to Karachi (KHI)?

via Islamabad ≈ 3h 5m, via Tashkent ≈ 3h 30m, via Mashhad ≈ 3h 42m (estimated flying time, excluding layovers).

Dushanbe International Airport (DYU) to Jinnah International Airport (KHI)・1,524 km

No nonstop flights. The fastest connection is via Islamabad (ISB), about 3h 5m of flying time (layover not included).

None.

5 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.