Are there nonstop flights from Detroit (DTW) to Mexico City (MEX)?

Yes. Delta Air Lines fly this route. Flight time is about 3h 57m.

What is the fastest connection from Detroit (DTW) to Mexico City (MEX)?

via Houston ≈ 4h 29m, via Querétaro ≈ 4h 35m, via Austin ≈ 4h 35m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Detroit Metropolitan Wayne County Airport (DTW) to Mexico City Benito Juárez International Airport (MEX)・2,933 km

Nonstop flights available (1 airline). Flight time about 3h 57m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via IAH)JAL 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

34 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.