Are there nonstop flights from Detroit (DTW) to Lexington (LEX)?

Yes. Delta Connection fly this route. Flight time is about 1h 4m.

What is the fastest connection from Detroit (DTW) to Lexington (LEX)?

via Chicago ≈ 2h 4m, via Charlotte ≈ 2h 29m, via Washington ≈ 2h 33m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

Detroit Metropolitan Wayne County Airport (DTW) to Blue Grass Airport (LEX)・477 km

Nonstop flights available (1 airline). Flight time about 1h 4m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.