Are there nonstop flights from Detroit (DTW) to Johannesburg (JNB)?

No. The fastest connection is via Newark, about 17h 3m of total flying time.

What is the fastest connection from Detroit (DTW) to Johannesburg (JNB)?

via Newark ≈ 17h 3m, via Atlanta ≈ 18h 7m, via Paris ≈ 18h 46m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 47,000 JAL miles (economy, one way, based on the published award charts).

Detroit Metropolitan Wayne County Airport (DTW) to O.R. Tambo International Airport (JNB)・13,648 km

No nonstop flights. The fastest connection is via Newark (EWR), about 17h 3m of flying time (layover not included).

With milesANA 35,000 miles+ (via EWR)JAL 47,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.