Are there nonstop flights from Detroit (DTW) to Rome (CIA)?

No. The fastest connection is via Amman, about 15h 12m of total flying time.

What is the fastest connection from Detroit (DTW) to Rome (CIA)?

via Amman ≈ 15h 12m (estimated flying time, excluding layovers).

Detroit Metropolitan Wayne County Airport (DTW) to Ciampino–G. B. Pastine International Airport (CIA)・7,451 km

No nonstop flights. The fastest connection is via Amman (AMM), about 15h 12m of flying time (layover not included).

None.

1 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.