Are there nonstop flights from Detroit (DTW) to Cairo (CAI)?

No. The fastest connection is via Toronto, about 12h 15m of total flying time.

What is the fastest connection from Detroit (DTW) to Cairo (CAI)?

via Toronto ≈ 12h 15m, via Paris ≈ 12h 16m, via London ≈ 12h 16m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Detroit Metropolitan Wayne County Airport (DTW) to Cairo International Airport (CAI)・9,569 km

No nonstop flights. The fastest connection is via Toronto (YYZ), about 12h 15m of flying time (layover not included).

With milesANA 35,000 miles+ (via FRA)JAL 37,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.