Are there nonstop flights from Cancún (CUN) to Des Moines (DSM)?

No. The fastest connection is via Nashville, about 3h 58m of total flying time.

What is the fastest connection from Cancún (CUN) to Des Moines (DSM)?

via Nashville ≈ 3h 58m, via Houston ≈ 4h 3m, via Houston ≈ 4h 4m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Cancún International Airport (CUN) to Des Moines International Airport (DSM)・2,366 km

No nonstop flights. The fastest connection is via Nashville (BNA), about 3h 58m of flying time (layover not included).

With milesANA 15,000 miles+ (via IAH)JAL 15,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

20 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.