Are there nonstop flights from Columbus (CMH) to Chicago (MDW)?

Yes. Southwest Airlines fly this route. Flight time is about 1h 2m.

What is the fastest connection from Columbus (CMH) to Chicago (MDW)?

via Detroit ≈ 1h 44m, via St Louis ≈ 2h 15m, via Nashville ≈ 2h 23m (estimated flying time, excluding layovers).

John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)・454 km

Nonstop flights available (1 airline). Flight time about 1h 2m. Nonstop return flights also operate.

3 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.