Are there nonstop flights from Columbus (CMH) to Istanbul (IST)?

No. The fastest connection is via Montréal, about 11h 11m of total flying time.

What is the fastest connection from Columbus (CMH) to Istanbul (IST)?

via Montréal ≈ 11h 11m, via Toronto ≈ 11h 12m, via Detroit ≈ 11h 18m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

John Glenn Columbus International Airport (CMH) to İstanbul Airport (IST)・8,648 km

No nonstop flights. The fastest connection is via Montréal (YUL), about 11h 11m of flying time (layover not included).

With milesANA 27,500 miles+ (via YYZ)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.