Are there nonstop flights from Charlotte (CLT) to Valletta (MLA)?

No. The fastest connection is via New York, about 10h 42m of total flying time.

What is the fastest connection from Charlotte (CLT) to Valletta (MLA)?

via New York ≈ 10h 42m, via Madrid ≈ 10h 43m, via Rome ≈ 10h 54m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Charlotte Douglas International Airport (CLT) to Malta International Airport (MLA)・8,233 km

No nonstop flights. The fastest connection is via New York (JFK), about 10h 42m of flying time (layover not included).

With milesANA 27,500 miles+ (via MUC)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.