Are there nonstop flights from Charlotte (CLT) to Istanbul (IST)?

No. The fastest connection is via Frankfurt am Main, about 11h 28m of total flying time.

What is the fastest connection from Charlotte (CLT) to Istanbul (IST)?

via Frankfurt am Main ≈ 11h 28m, via London ≈ 11h 28m, via Dublin ≈ 11h 28m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 40,000 JAL miles (economy, one way, based on the published award charts).

Charlotte Douglas International Airport (CLT) to İstanbul Airport (IST)・8,896 km

No nonstop flights. The fastest connection is via Frankfurt am Main (FRA), about 11h 28m of flying time (layover not included).

With milesANA 27,500 miles+ (via MUC)JAL 40,000 miles+ (via LHR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

28 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.